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Chat with Professor Vande Geest

We Develop Novel Solutions
That Improve Human Health

Integrating Mechanobiology, Biofabrication,
& Computational Biomechanics

Research Areas

Investigating the role of the extracellular matrix in disease and leveraging these insights for translational regenerative medicine.

Mechanobiology & Extracellular Matrix Remodeling in Disease

Introduction

The health and viability of soft tissues are closely governed by the mechanobiology of cells and their surrounding extracellular matrix (ECM). It is also known that the organization and stiffness of the ECM play an integral role in many human diseases. Research efforts within the STBL are therefore focused on identifying the structure function relationships of the ECM and how this plays a role in human disease. In this theme of research, advances in bioengineering are established in the STBL by seamlessly integrating state-of-the-art techniques in intra-vital nonlinear optical microscopy (multiphoton imaging), tissue characterization, cell mechanobiology, and finite element modeling.

Publications

Design and Biomanufacturing of Engineered Tissue

Introduction

The structure function relationships of the ECM as described above are then used by our laboratory to biomanufacture soft tissues for regenerative medicine and tissue engineering purposes. The STBL utilizes several biomanufacturing tools in this endeavor including but not limited to electrospinning, two photon polymerization, spray phase separation, and 3D bioprinting. A tightly integrated experimental and computational optimization approach is utilized to fabricate the next generation of engineered tissues to treat human disease.

Publications

Our Team

Our team is a diverse group of scientists and engineers who unite their expertise in mechanobiology, biofabrication, and computational biomechanics to advance the understanding of biological systems.

Jonathan Vande Geest, PhD

Principal Investigator

Ali Behrangzade

Research Assistant Professor, CEO EV2 Technologies, Inc

Jincy Joy

Postdoctoral Fellow

David R. Maestas, Jr.

Postdoctoral Fellow

Adam Forrest

PhD Candidate BioE (w/Kozai Lab)

Katarina Martinet

PhD Candidate Bioengineering

Tiffany Moreno

PhD Candidate Bioengineering

Tracey Moyston

PhD Candidate BioE (w/ Little Lab)

Remi Shittu

PhD Candidate Bioengineering

Pang-Wei Liu

MS Student Bioengineering

Meredith Geno

Undergraduate Researcher

Grace Malloy

Undergraduate Researcher

Trin Murphy

Undergraduate Researcher

Nate Myers

Undergraduate Researcher

Colleen O'Malley

Undergraduate Researcher

Brock Pemberton

Undergraduate Researcher

Nadia Saba

Undergraduate Researcher

Nick Vasas

Undergraduate Researcher

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